Research & Facts
Evidence-based research, clinical studies, and scientific facts about Cannabinoid Hyperemesis Syndrome (CHS).
Research Timeline
Historical development and key milestones in CHS research
First Medical Description
Allen et al. published the first case series in Gut journal, describing 9 patients with chronic cannabis use who developed cyclic vomiting relieved by hot showers.
Diagnostic Criteria Established
Sontineni et al. published diagnostic criteria in World Journal of Gastroenterology, providing the first standardized approach to CHS diagnosis.
HaVOC Trial
Landmark randomized controlled trial showing haloperidol superiority over ondansetron for CHS symptoms.
AGA Clinical Practice Update
American Gastroenterological Association releases comprehensive clinical guidance for CHS management.
Scientific Evidence
Key research findings and clinical evidence supporting CHS
Prevalence Studies
About 33% of frequent cannabis users report CHS symptoms, suggesting approximately 2.7 million affected Americans annually.
Genetic Research
Studies identified mutations in genes related to TRPV1 receptor, dopamine signaling, and drug metabolism (CYP2C9) associated with CHS susceptibility.
Russo et al. (2024) - Cannabinoid hyperemesis syndrome: genetic susceptibility to toxic exposure
Treatment Efficacy
Clinical trials demonstrate haloperidol's effectiveness for acute episodes, with significant symptom reduction compared to standard antiemetics.
Pathophysiology
Understanding how CHS develops in the body
Receptor Desensitization
Chronic CB1 receptor stimulation leads to paradoxical effects on emetic pathways.
Long-term cannabis exposure may alter normal endocannabinoid system function.
Genetic Factors
Specific genetic variations affect individual susceptibility to CHS.
Mutations in TRPV1, dopamine pathways, and metabolism genes contribute to risk.
Hot Water Response
TRPV1 receptor activation explains temporary symptom relief from hot water.
Temperature-dependent activation modulates substance P and other nausea pathways.
Common Myths Debunked
Scientific examination of common misconceptions
Myth: CHS is caused by pesticides
Reality: Research shows pesticide levels are too low to cause CHS symptoms. Cases occur with tested and organic cannabis.
Evidence: Russo et al. (2024) - Cannabinoid hyperemesis syndrome: genetic susceptibility to toxic exposure
Myth: CHS is just Cyclic Vomiting Syndrome
Reality: CHS has distinct features including cannabis use history and hot shower relief.
Myth: Moderate use prevents CHS
Reality: Once CHS develops, any THC exposure typically triggers symptoms.